Photodegradation of Moxifloxacin in Aqueous and Organic Solvents: A Kinetic Study

The results indicate that the current method is highly accurate and precise for the determination of MF with better system suitability

Iqbal Ahmad

2014

Scholarcy highlights

  • Moxifloxacin-4-oxo1,4-dihydro-3-quinoline carboxylic acid) is a synthetic, broad spectrum fluoroquinolone antimicrobial agent that shows in vitro activity against Gram-positive and Gramnegative organisms, as well as atypical organisms and anaerobes
  • For the identification of photodegraded products formed in acid and alkaline solutions, 1 mg/ml solution of MF was irradiated under the same conditions for 24–30 h and the solutions were used for LC–MS/MS analysis
  • The results of this study show that MF on UV irradiation in acid solution leads to the formation of five photodegraded products and in alkaline solution three photodegraded products
  • MF undergoes several acid-base equilibria in aqueous solution and its photodegradation depend on the reactivity of the particular ionic species present in the pH range
  • Pathways have been proposed for the photodegradation of MF in acid and alkaline media in the light of the products identified
  • The results indicate that the current method is highly accurate and precise for the determination of MF with better system suitability
  • The photodegradation of MF in organic solvents depends on solvent characteristics and the rate constants for degradation are a linear function of solvent dielectric constants and an inverse function of solvent viscosity

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