Preparation, Characterization, Pharmacokinetics and Tissue Distribution of Solid Lipid Nanoparticles Loaded with Tetrandrine

Solid lipid nanoparticles have been widely investigated as an alternative drug delivery system, for poorly water-soluble lipophilic drugs

Su Li

2011

Scholarcy highlights

  • Solid lipid nanoparticles have been widely investigated as an alternative drug delivery system, for poorly water-soluble lipophilic drugs
  • solid lipid nanoparticles combine the advantages of polymeric nanoparticles, fat emulsions, and liposomes
  • The EE of TET–SLNs was calculated using the following equation: EE ð%Þ 1⁄4 W1 Â 100% W2 where, W1 was the amount of TET in SLNs and W2 was the amount of TET added in the formulations
  • For the first group of lipids tested, myristic acid, palmitic acid, stearic acid, behenic acid, glyceryl monostearate, Compritol® 888 ATO, and Precirol® ATO 5 were screened as the potential components of the lipid phase
  • TET exhibited a low solubility in GM and PA, stable nanoparticle formulations of TET could be prepared with these lipids
  • The size of the SLNs determined by the Laser Particle Size Analyzer was not consistent with the transmission electron microscopy results
  • The described system may offer an alternative approach to intravenous delivery of tetrandrine

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