Application of In Situ Polymerization for Design and Development of Oral Drug Delivery Systems

This review focuses on highlighting the different techniques of in situ polymerization for oral drug delivery systems with emphasis on drug incorporation during polymerization

Ndidi Ngwuluka

2010

Scholarcy highlights

  • It is a veritable truism that polymers are inevitable in drug delivery
  • Acrylic acid monomers were utilized as the pH-responsive component and to tailor the coatings to trigger drug release at different pH, hydrophobic monomers such as lauryl acrylate, or octadecyl acrylate were copolymerized with AA which increased the pKa of AA and, in turn, pH which initiated swelling of the hydrogel formed after polymerization
  • Micellar copolymerization is a process of modifying water soluble polymers to possess hydrophobic groups
  • It consists of copolymerizing a mixture of hydrophilic and hydrophobic monomers whereby the hydrophobic monomers are within the surfactant micelles and the hydrophilic monomers are within the aqueous continuous phase containing an initiator
  • The method permits the manipulation of the monomer distribution which enables the production of a polymer with tailored properties
  • The fact that micellar copolymerization can be undertaken at low temperatures enables incorporation of proteins, polypeptides, and heatlabile drugs, whose stability and bioactivity can be augmented by mild encapsulating approach
  • Amphiphilic polymers thereby produced have extended-release properties due to the hydrophobic groups within the polymers

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