Lipocortins, a Family of Phospholipase A2-Inhibitory Proteins

We provide a short history of the discovery of the lipocortin family, establish their relationship to other previously described calcium phospholipid-binding proteins, and reviews what is known about six members of this family

Barbara P. Wallner

2020

Scholarcy highlights

  • We provide a short history of the discovery of the lipocortin family, establish their relationship to other previously described calcium phospholipid-binding proteins, and reviews what is known about six members of this family
  • Lipocortins were first discovered as potential mediators of steroid action
  • Anti-inflammatory steroids inhibit the production of eicosanoids by inhibiting the release of arachidonic acid
  • The epidermal growth factor receptor is a membrane-associated protein tyrosine kinase, which when activated through the binding of epidermal growth factor, phosphorylates cellular proteins that may have important roles in growth regulation
  • The discovery of the lipocortin family of calcium phospholipid-binding proteins has established an important link in the signal transduction process

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