Our study demonstrated constitutive activation of the mitogen-activated protein kinase pathway in UC5; low MAPK12 expression was associated with higher probability of overall survival
2009
Key concepts
Scholarcy highlights
- Current urothelial carcinoma management primarily depends on histologic grading and pathologic staging of the tumor. these provide assessment of risk, they are unable to predict outcome in an individual patient
- In univariate analysis, six genes were significantly associated with time to recurrence, and 10 with overall survival
- Of all genes identified by either univariate or partitioning analysis, four were found to significantly predict both recurrence and survival; overexpression was associated with worse outcome
- The prognostic potential of this four-gene panel was confirmed in a large independent external cohort
- Clinicopathologic Parameters and Clinical Outcome Associations of clinicopathologic parameters of the study cohort with outcome are listed in Table 1
- Pathologic stage was significantly associated with overall survival but not with time to recurrence
- We have documented the generation of a concise, biologically relevant four-gene panel that significantly predicts recurrence and survival and may identify potential therapeutic targets for urothelial carcinoma
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