Generation of a Concise Gene Panel for Outcome Prediction in Urinary Bladder Cancer

Our study demonstrated constitutive activation of the mitogen-activated protein kinase pathway in UC5; low MAPK12 expression was associated with higher probability of overall survival

Anirban P. Mitra

2009

Scholarcy highlights

  • Current urothelial carcinoma management primarily depends on histologic grading and pathologic staging of the tumor. these provide assessment of risk, they are unable to predict outcome in an individual patient
  • In univariate analysis, six genes were significantly associated with time to recurrence, and 10 with overall survival
  • Of all genes identified by either univariate or partitioning analysis, four were found to significantly predict both recurrence and survival; overexpression was associated with worse outcome
  • The prognostic potential of this four-gene panel was confirmed in a large independent external cohort
  • Clinicopathologic Parameters and Clinical Outcome Associations of clinicopathologic parameters of the study cohort with outcome are listed in Table 1
  • Pathologic stage was significantly associated with overall survival but not with time to recurrence
  • We have documented the generation of a concise, biologically relevant four-gene panel that significantly predicts recurrence and survival and may identify potential therapeutic targets for urothelial carcinoma

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