Molecular identification and antimicrobial activities of some wild Egyptian mushrooms: Bjerkandera adusta as a promising source of bioactive antimicrobial phenolic compounds

Our finding provides a quick and robust implement for mushroom identification that would facilitate mushroom domestication and characterization for human benefit

Elham R. S. Soliman

2021

Scholarcy highlights

  • The discovery of potential, new cost-effective drug resources in the form of bioactive compounds from mushrooms is one way to control the resistant pathogens
  • Chemical composition of the crude extract of Cyclocybe cylindracea and Agrocybe aegerita fruiting bodies Even identified differentially, Mush 2 and 3 show 100% similarity based on the sequenced internal transcribed spacer region-rDNA fragment that argues for the same species for both samples; dissimilar antimicrobial activities were detected
  • All the sequences were deposited into the National Center for Biotechnology Information database and the acquired accession numbers are listed in Table 1 with the Basic Local Alignment Search Tool results
  • The results show a maximum similarity of 100% was detected between Cyclocybe cylindracea and Agrocybe aegerita while the lowest similarity was detected between Chlorophyllum molybdites and all other mushrooms, Table 2 and Fig. 3
  • Detailed phylogenetic analyses showed that all mushroom samples fall into three major clades; Cyclocybe cylindracea and Agrocybe aegerita were genetically identical and separated together in one clade while Lentinus squarrosulus show ~82% pairwise similarity to Bjerkandera adusta and so both of them are represented in the second clade
  • The mechanism of antibacterial action of the best extracts should be elucidated and the individual/combined compounds found in those extracts might be tested against selected bacteria to identify molecules responsible for the bioactivity

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