MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

This study showed that the knockdown of REGγ significantly elevates the stability of the MYC protein

Seyed Esmaeil Ahmadi; Samira Rahimi; Bahman Zarandi; Rouzbeh Chegeni; Majid Safa

2021

Scholarcy highlights

  • MYC is a super-transcription factor encoded by the MYC gene located at chromosome 8 q24.21
  • The chromatin-modifying complex consisting of TIP60, TRRAP, TIP48, and GCN5 recruited by MYC/ Max heterodimer propels transcription through binding to the E-box DNA region within the regulatory domain of target genes
  • Studies have shown that even temporary inactivation of MYC abrogates tumor progression, implying that MYC regulation could be a potential strategy to treat MYC-involved cancers
  • MYC does not possess a specific active site to be targeted by small molecules
  • MYC is mainly found in the nucleus; targeting MYC with antibodies is not feasible
  • Future clinical studies will have to evaluate whether MYC should be targeted directly or indirectly in order to achieve a proper therapeutic outcome

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