We reviewed the bibliography of prior meta-analyses, review articles, and studies that underwent full-text screening for additional studies to maximize the yield
2019
The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data
Key concepts
Scholarcy highlights
- Peppermint oil has intrinsic properties that may benefit patients with irritable bowel syndrome symptoms
- A total of 427 studies remained for a review of titles and abstracts, from which 22 trials were identified that underwent full text screening
- Lech et al failed to utilize any validated inclusion criteria, though they did find a significant benefit for PO relative to placebo for improvements in abdominal pain
- Liu et al failed to utilize any validated inclusion criteria, though they did find a significant benefit for PO relative to placebo for the improvement of abdominal pain
- The risk ratio for seven randomized controlled trials for the effect of PO versus placebo on global symptoms was 2.39, I2 = 0%, z = 7.93
- There was no statistically significant difference in reported adverse effects in IBS subjects using PO versus placebo; RR 1.40, I2 = 0%, z = 1.39
- Five studies for data that was shown in other publications, four RCTs were cross-over trials without sufficient washout period, and an RCT was permitted rescue medication without sufficient data to permit analysis.
Need more features? Save interactive summary cards to your Scholarcy Library.