A randomised controlled trial of a personalised lifestyle coaching application in modifying periconceptional behaviours in women suffering from reproductive failures (iPLAN trial)

Lifestyle, in particular obesity and smoking has significant impacts on fertility and an important focus for the treatment of reproductive failures is the optimisation of periconceptional lifestyle behaviours

Ka Ying Bonnie Ng; Susan Wellstead; Ying Cheong; Nick Macklon

2018

Scholarcy highlights

  • Lifestyle, in particular obesity and smoking has significant impacts on fertility and an important focus for the treatment of reproductive failures is the optimisation of periconceptional lifestyle behaviours
  • The impact of lifestyle, and in particular obesity and smoking on fertility has been well described, and optimizing preconceptional lifestyle behaviours has become a primary strategy in the treatment of subfertility, recurrent pregnancy losses, and in particular the management of anovulation secondary to polycystic ovary syndrome
  • It is becoming clear that the preimplantation intrauterine environment is a key determinant of embryo development and early programming, and recent work has shown that the nutritional content of endometrial secretions is directly affected by diet
  • The effectiveness of the smartphone application in changing lifestyle choices has not been studied in women with subfertility or in those suffering from recurrent miscarriages
  • Study objective The prospective randomised controlled trial aims to address the question of whether an online based lifestyle coaching application is an effective means of delivering periconceptional advice in women suffering from reproductive failures
  • With this study, we aim to clarify whether a personalised online smartphone-based lifestyle coaching application is more effective at improving behaviours than standard advice offered by National Health Service resources
  • Abbreviations GCP : Good Clinical Practice; iPLAN: Impact of a Personalised Lifestyle coaching phone ApplicatioN in modifying peri-conceptional behaviours; IRAS : Integrated Research Application System; NHS: National Health Service; NICE: The National Institute of Health and care Excellence

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