Patterns of heart rate variability and cardiac autonomic modulations in controlled and uncontrolled asthmatic patients

This is because the present results suggested augmented parasympathetic and depressed sympathetic autonomic modulations in controlled asthmatic compared with Uncontrolled asthma patients but fail to demonstrate similar differences in autonomic trends when the asthmatic subjects group was compared with healthy control subjects

Mohamed Faisal Lutfi


Scholarcy highlights

  • Previous heart rate variability studies in asthmatic subjects demonstrate predominance of parasympathetic drive concomitant with low HRV, which is against the general belief that enhanced parasympathetic modulation improves HRV
  • Adjustment for mean heart rate and asthma treatments nullified all significant variations between healthy control subjects and controlled asthmatic but all other differences between CA and Uncontrolled asthma patients remained statistically significant. It is evident from the present results that global HRV and autonomic modulations of CA patients are significantly different from UA patients irrespective of the possible influences of MHR and AAT on HRV
  • CA patients showed higher HRV and augmented vagal modulation compared with HS, these findings were no longer significant following adjustment for MHR and AAT
  • The present results confirmed that degree of asthma control influences pattern of autonomic modulations/HRV among AS
  • Enhanced parasympathetic modulations offered higher HRV to CA compared with UA patients who suffered from attenuated vagal tone
  • Neither CA nor UA patients were shown to have different autonomic modulations and/or HRV compared with HS
  • The comparable autonomic modulations/heart rate variability among asthmatic subjects and healthy control subjects, different to several previous reports, were based on a well-designed comparison that considered possible influences of mean heart rate and asthma treatments on HRV

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