Evaluation of gray matter perfusion in episodic migraine using voxel-wise comparison of 3D pseudo-continuous arterial spin labeling

The aim of this study is to investigate altered gray matter perfusion in episodic migraine using a 3D volumetric perfusion imaging

Zhiye Chen

2018

Scholarcy highlights

  • Previous studies have demonstrated that structural and functional abnormalities in episodic migraine, less is known about altered brain perfusion in the EM
  • The image processing included following steps: The structural images were segmented into grayand white matter tissue probability maps using DARTEL methods, which simultaneously generated the normalized T1 tissue probabilitymaps; All the T1-TPM wereused to generate average T1-TPM and further generate brain mask; The individual cerebral blood flow maps were spatially normalize into strandard Montreal Neurologic Institute stereotaxic space by coregistering with the individual T1-TPM and resampled into 1.5 × 1.5 × 1.5 mm3 isotropic size, which would generated individual normalized CBF maps; The individual nCBF maps were warped by the brain mask to extract brain tissue; The individual normalized CBF maps with brain extractionwere performed Z transformation to avoid individual hemodynamic variation, and spatially smoothed with a 6-mm isotropic Gaussian kernel
  • Comparison of gray matter perfusion between EM and normal controls The brain region with increased perfusion located in the left Brodmann 38
  • In conclusion, this study revealed that the interictal hyperperfusion in left temporal pole and vlPFC may reflect the neural metabolism abnormality regarding multi-dimensional pain processing in migraine
  • The pattern of cerebral hyperperfusion at interictal migraine may elucidate the neurogenic mechanism in the EM genesis. 3D 3D pseudo-continuous arterial spin labeling technique would non-invasively provide valuable cerebral perfusion information for the further pathophysiological and neuropsychological study in EM
  • Abbreviations 3D pc-ASL: 3D pseudo-continuous arterial spin labeling; BA38: Brodmann 38; bet_nCBF: normalized CBF maps with brain extraction; CBF: cerebral blood flow; EM: episodic migraine; GM-TPM: gray matter tissue probability map; HAMA: Hamilton Anxiety Scale; HAMD: Hamilton Depression Scale; MA: migraine with aura; MIDAS: migraine disability assessment scale; MO: migraine without aura; NC: normal controls; nCBF: normalized CBF maps; perfusion-weighted MR imaging: perfusion-weighted imaging; SPECT: single photon emission computed tomography; T1-TPM: T1 tissue probability maps; TP: temporal pole; VAS: visual analogue scale; WM-TPM: white matter tissue probability map

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