Predictors of disease progression in HIV infection: a review

A greater than threefold increase in viral load has been associated with increased risk of clinical deterioration and so this value is recommended to guide therapeutic regimen change in the developed world

Simone E Langford


Scholarcy highlights

  • Host factors such as age, Human Leukocyte Antigen and CYP polymorphisms and psychosocial factors remain important, though often unalterable, predictors of disease progression
  • Readily measurable markers of disease such as total lymphocyte count, haemoglobin, body mass index and delayed type hypersensitivity may come into favour as ART becomes increasingly available in resource-limited parts of the world
  • The influence of these, and other factors, on the clinical progression of Human Immunodeficiency Virus infection are reviewed in detail, both preceding and following treatment initiation
  • Immune-activation-driven apoptosis of CD4+ cells, more than a direct virological pathogenic effect, is responsible for the decline in CD4+ T-lymphocytes seen in HIV infection
  • RNA are the gold standard markers for disease monitoring, when measurement of these parameters is not possible surrogate markers become important. Markers investigated for their utility as simple markers for disease progression in resource-limited settings include delayed type hypersensitivity responses, total lymphocyte count, haemoglobin and body mass index
  • The evolution of HIV infection from the fusion of the first virion with a CD4+ T-cell to AIDS and death is influenced by a multitude of interacting factors
  • As with any illness of such magnitude, it is clear that a multitude of factors must be taken into account in order to ensure optimum quality of life and treatment results

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