Noninvasive detection of lung cancer by analysis of exhaled breath

In the present manuscript we present results obtained with gas chromatography and mass spectrometry with preconcentration by solid phase microextraction, and results obtained with proton transfer reaction mass spectrometry

Amel Bajtarevic

2009

Scholarcy highlights

  • Lung cancer is one of the leading causes of death in Europe and the western world
  • In the present manuscript we present results obtained with gas chromatography and mass spectrometry with preconcentration by solid phase microextraction, and results obtained with proton transfer reaction mass spectrometry
  • Concentrations of volatile organic compounds as determined by PTR-MS The distribution of concentrations for benzene, isoprene, acetone and methanol was determined by PTR-MS
  • All the 21 compounds used here for detection of lung cancer patients were not observed in healthy controls at concentrations at least 15% higher in exhaled breath than in indoor air
  • Typical compounds arising in everybody's exhaled breath are isoprene, acetone and methanol, which exhibit decreased concentrations in breath of lung cancer patients as compared to healthy controls
  • Many other compounds arise in lung cancer patients only
  • An important issue is the validated identification of volatile compounds observed in breath by comparison with commercially available pure compounds, since many observed compounds from exhaled breath have not been considered before in medical or biochemical context

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