Anti-Vancomycin-resistant Enterococcus faecium and E. faecalis Activities of (-)-Gossypol and Derivatives from Thespesia garckeana

Compound 2 was more potent than 1 against the low level vancomycin-resistant Enterococcus faecium strain with IC50/MIC/MBC values of 4.34/9.40/9.40 μM

Veronica M. Masila; Jacob O. Midiwo; Jin Zhang; Bonface M. Gisacho; Renee Munayi; Leonidah K. Omosa; Frank T. Wiggers; Melissa R. Jacob; Larry A. Walker; Ilias Muhammad

2019

Scholarcy highlights

  • Compound 2 was more potent than 1 against the low level vancomycin-resistant Enterococcus faecium strain with IC50/MIC/MBC values of 4.34/9.40/9.40 μM
  • Compound 1 demonstrated modest activity against the other microbes tested including C. glabrata, S. aureus and methicillin-resistant S. aureus with IC50 values of 0.73, 9.15 and 8.99 μM, respectively

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