Evidence that abnormally large seasonal declines in vitamin D status may trigger SLE flare in non-African Americans

We identified for this study 82 flares from 46 patients that were separated by at least 8 months from previous flares

DJ Birmingham


Scholarcy highlights

  • For flares occurring during high daylight months, 25(OH)D levels changed only in non-AA patients, increasing slightly
  • This study took into account the seasonal effect of sunlight exposure and skin pigmentation, two factors known to influence the levels of circulating vitamin D.41,43
  • Levels during LDM, as determined for the matching “no-flare” intervals that occurred in the same calendar months
  • The present work is consistent with the hypothesis that during LDM, a larger than usual decline in vitamin D status is a mechanism of systemic lupus erythematosus
  • In the non-AA patient flares, there was a small but significant increase in the median 25(OH)D levels at the time of flare, compared to the −4 month level
  • The mechanism may involve a reduction in the roles played by vitamin D in modulating both the immune response and the inflammatory response
  • Analysis of all of the 201 flares in the Ohio SLE Study suggests this to be true, with a trend in non-AA patients for a higher overall flare rate during LDM than during high daylight months

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