Study of muscular effects of short-term pyridostigmine treatment in resting and exercising rats

The present study was undertaken to investigate in a rat model the potential muscle damage produced by this pretreatment when given alone or combined with physical exercise

Michel Hubert; Dominique Lison

2008

Scholarcy highlights

  • The present study was undertaken to investigate in a rat model the potential muscle damage produced by this pretreatment when given alone or combined with physical exercise
  • No evidence was found of a deleterious effect of this treatment on the skeletal muscle
  • Following physical exercise, the same treat ment significantly exacerbated the biochemical changes reflecting a loss of integrity in skeletal muscles, namely, increased creatine phosphokinase and urinary creatine excretion rate
  • The significance of this observation remains to be clarified

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