Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling

We describe a Th22 subset of T cells, which was clearly separate from Th17 and other known T cell subsets

Stefanie Eyerich

2009

Scholarcy highlights

  • Th subsets play a discriminative role in translating antigen-specific immune responses into tissue functions or immunopathology
  • IL-22 belongs to the IL-10 cytokine family and binds to a heterodimeric receptor consisting of the IL10 receptor β chain and the IL-22R
  • atopic eczema-derived T cells were characterized by a large proportion of IL-4–expressing T cells, whereas PSand allergic contact dermatitis-derived T cells showed a prevalence of IFN-γ–expressing T cells
  • The IL-17–expressing population was largest in PS, followed by ACD and AE
  • This IL-17–expressing population overlapped with IFN-γ–producing T cells and, to a lesser degree, with those expressing IL-4, whereas approximately 50% were pure Th17 cells
  • Interindividual differences were high, the frequency of IL-22+ T cells was significantly higher in skinderived T cell lines than in the circulation
  • The expression profile clearly identified Th22 cells as a separate subset, including subsetspecific surface receptors and transcription

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