Late Stent Thrombosis

This seminal observation triggered a wave of observations; the cases of late stent thrombosis after brachytherapy accrued month after month until the pioneer in the field, Ron Waksman, courageously admitted in an editorial that we were “sitting on a time bomb.”3 Five years later, in the beginning of the drug-eluting stent era, we reported, together with Waksman’s group, the first 4 cases of late ST.4

Patrick W. Serruys; Joost Daemen

2007

Scholarcy highlights

  • Late stent thrombosis is for us an old foe that we have tracked repeatedly throughout the history of interventional cardiology
  • A few years later, when some believed that they had discovered the universal panacea for restenosis, we were the first to report in the literature 6 cases of late ST in 100 patients having undergone brachytherapy after stent implantation
  • This seminal observation triggered a wave of observations; the cases of late ST after brachytherapy accrued month after month until the pioneer in the field, Ron Waksman, courageously admitted in an editorial that we were “sitting on a time bomb.” Five years later, in the beginning of the drug-eluting stent era, we reported, together with Waksman’s group, the first 4 cases of late ST
  • We are not trying to minimize the phenomenon, and we recognize that we are describing only the tip of the iceberg by disregarding fatal myocardial infarction and unexplained death as clinical surrogates of ST, but we do not believe that 0.6% per year could, by any means, be compared with the 6% late ST seen after vascular brachytherapy
  • Late ST exists in both DES and bare metal stent
  • A first consensus on these angiographic and clinical end-point definitions has been reached under the umbrella of the Academic Research Consortium
  • Retrospective analysis of stent thrombosis, applying the Academic Research Consortium definitions in randomized controlled trials, does not disclose a different rate of late ST between bare metal stent and drug-eluting stent up to 4 years

Need more features? Save interactive summary cards to your Scholarcy Library.