Development of the Coronary Vessel System

We present the descriptive embryology of this process as well as the recent data that shed light on the unique developmental mechanisms underlying generation of coronary vessels

David E. Reese; Takashi Mikawa; David M. Bader

2002

Scholarcy highlights

  • Formation of the coronary vessels is a fundamental event in heart development
  • The basic pathways taken by major coronary vessels over the surface of the heart are presented in cardiology textbooks, there is much variation in the pattern that is not well understood
  • All the cells that make up the coronary system come from outside the heart are brought to the heart and differentiate into blood vessels only when they are in the heart
  • For purposes of describing the overall structure of the coronary system, we focus on studies of the human heart
  • The identification of myocardial factors regulating the delamination of vasculogenic precursors is essential for an understanding of coronary vessel development and should provide new concepts for the study of epithelial-tomesenchymal transition in various embryonic systems
  • Culture of the proepicardial organ and analysis of the resulting cell phenotypes show the presence of the predicted cells after a period of growth and differentiation, Further, analysis of protein expression such as Bves, a putative cell adhesion molecule expressed in coronary vessel precursor cells, in epicardially derived cells has shown the pervasive nature of mesenchymal migration in the myocardium
  • Many studies have demonstrated that the interaction between angioblasts/endothelial cells with mesenchyme is essential for the commitment and differentiation of smooth muscle. While the expression patterns of the main signaling molecules and transcription factors governing smooth muscle development in the coronary system are being completed, it would seem unlikely that novel regulatory mechanisms would be identified in coronary vasculogenesis

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