Comparative Study on the Cytostatic Effects and the Tissue Distribution of 5-Fluorouracil in a Free Form and Bound to Polybutylcyanoacrylate Nanoparticles in Sarcoma 180-Bearing Mice

The binding of 5-ftuorouracil to polybutylcyanoacrylate nanoparticles yielded an enhanced efficacy against Crocker sarcoma S 180 and a higher toxicity of the drug measured by induced leukopenia, body weight loss and premature death

Jörg Kreuter

2009

Scholarcy highlights

  • The binding of 5-ftuorouracil to polybutylcyanoacrylate nanoparticles yielded an enhanced efficacy against Crocker sarcoma S 180 and a higher toxicity of the drug measured by induced leukopenia, body weight loss and premature death
  • The efficacy was further increased by an increase in the polymer-to-drug ratio
  • The nanoparticles yielded a prolonged persistence of the 5-fluorouracil in all organs examined including the tumor
  • These particles hold promise as carriers for cytostatics, since their distribution may be favorably altered by coating them with certain proteins or surfactants or by the attachment of monoclonal antibodies

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