Paroxetine in the Elderly: A Comparative Meta-Analysis against Standard Antidepressant Pharmacotherapy

The results indicate paroxetine is an alternative first-line therapy to these older antidepressants and should be considered when treating elderly patients

Geoffrey C. Dunbar

2008

Scholarcy highlights

  • Number of Print Pages: 8 Number of Figures: 0 Number of Tables: 0
  • In a meta-analysis often studies in elderly patients, paroxetine was as effective an antidepressant as active controls
  • The change over 5-6 weeks of therapy, on the Hamilton Depression Rating Scale, was significantly better with paroxetine compared with active controls
  • Paroxetine was effective in treating anxiety symptoms associated with depression, yet caused significantly less sedation compared with active controls
  • There was little difference in the overall safety profiles seen between the paroxetine and active control groups
  • The results indicate paroxetine is an alternative first-line therapy to these older antidepressants and should be considered when treating elderly patients

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