Effects of Growth Hormone Substitution Therapy on Cognitive Functioning in Growth Hormone Deficient Patients: A Functional MRI Study

We found an increased bilateral activity in dorsolateral

Lucia I. Arwert


Scholarcy highlights

  • The function of the growth hormone-insulin-like growth factor I axis as well as the cognitive functioning decline with aging
  • Six months of GH substitution in these GH deficiency patients resulted in improved memory functioning, both for long-term and working memory. functional magnetic resonance imaging showed activations during the working memory task in prefrontal, parietal, motor, and occipital cortices, as well as in the right thalamus and anterior cingulate cortex
  • GH substitution in GHD patients is beneficial for cognitive functioning, the effects of which can be visualized by means of neuroimaging
  • The present study was designed to investigate the effect of GH substitution therapy in patients with CO-GHD on cognitive functioning, especially memory performance
  • Six months of GH therapy did result in significantly increased values of serum IGF-I and IGF-binding protein 3, whereas no significant differences were observed in the placebo-treated group
  • The mood scale scores improved in both groups, while no difference between the GH and placebo group was observed
  • After GH substitution, we observed a decreased activity in the VLPFC as compared with placebo treatment. These results are in line with those of our previous study, in which we found an increased brain activation in GHD patients as compared with healthy matched controls
  • Future research should aim at replicating these findings in a larger group and at determining whether growth hormone substitution leads to improved memory function in other patients groups, such as patients with AO-GH deficiency, or in healthy elderly subjects with decreased insulin-like growth factor I levels

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