Stress and Atopic Dermatitis

This study shows the importance of stress as a factor for aggravation and development of atopic dermatitis

V. Benea; D. Muresian; L. Manolache; E. Robu; J.-D. Diaconu

2003

Scholarcy highlights

  • Atopy is a genetically determined disorder characterized by an increased liability to form Ig E antibodies and an increased susceptibility to certain diseases, especially extrinsic asthma, allergic rhinitis, allergic conjunctivitis, and certain types of food allergy; the main clinical type of dermatitis usually associated with atopy is atopic dermatitis
  • Many epidemiological studies indicate that the incidence of atopic dermatitis has doubled or tripled over past decades ; this increase is more evident in developed countries, where atopic dermatitis affects 10–20% of population
  • Links between free nervous terminations and resident cells of the skin were pointed out. These links are realized through the neuropeptides that are synthesized in the pericarion of the neurons and that transfer the nervous impulse from epithelium to central nervous system
  • This study shows that stress alone is not the most important trigger factor, but it is a very important factor in maintaining the dermatitis and the disease itself could be a stressor for the patient, opening a vicious circle
  • Stress is involved as a possible precipitating and aggravating factor in atopic dermatitis, and the disease itself can be a psychosocial stress, which maintains the disease. This fact is important in the management of patients with atopic dermatitis: psychotropic, antipsychotic, and anxiolytic drugs, antidepressants, and psychotherapy are recommended as additional treatment strategies
  • Very important in the treatment of atopic dermatitis are the psychotropic drugs with an antihistaminic effect

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