Apolipoprotein E and Intronic Polymorphism of Presenilin 1 and Alpha-1-Antichymotrypsin in Alzheimer’s Disease and Vascular Dementia

Apolipoprotein E genotypes, presenilin 1 and α1-antichymotrypsin polymorphism and the association of the genotypes were examined in patients with Alzheimer’s disease or vascular dementia in comparison with elderly controls

T. Rodriguez Martin; A.M. Calella; S. Silva; E. Munna; P. Modena; R. Chiesa; S. Terrevazzi; R.M. Ruggieri; R. Palermo; F. Piccoli; R. Confalonieri; P. Tiraboschi; C. Fragiacomo; P. Quadri; U. Lucca; G. Forloni

2003

Scholarcy highlights

  • Apolipoprotein E genotypes, presenilin 1 and α1-antichymotrypsin polymorphism and the association of the genotypes were examined in patients with Alzheimer’s disease or vascular dementia in comparison with elderly controls
  • The frequency of the ApoE ε4 allele was significantly increased both in late-onset AD and in VD; the frequency of ApoE ε2 was significantly reduced in AD, but it was similar in VD and controls
  • The presence of the allele 1 of PS-1 intronic polymorphism was not associated with AD or VD and was not influenced by the ApoE genotypes
  • The frequency of allele A of the intronic polymorphism of ACT was similar in AD, VD and controls and it was not altered by ApoE or PS-1 genotypes
  • The results confirm the association between ApoE ε4 and AD and indicate an increase in ApoE ε4 in Vd, too
  • No association was shown between ACT allele A and PS-1 allele 1 in AD or VD
  • Number of Print Pages: 6 Number of Figures: 0 Number of Tables: 3

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