Subtypes of Breast Cancer Show Preferential Site of Relapse

We explored whether the five previously reported molecular subtypes in breast cancer show a preference for organ-specific relapse and searched for molecular pathways involved

M. Smid


Scholarcy highlights

  • Molecular subtypes in breast cancer were first described byPerou et al who mapped the phenotypic diversity seen in breast cancer to a specific gene expression pattern
  • One sample switched from not labeled in the original data to normal-like in the new clustering; all other samples remained in the same clusters
  • We aimed to determine whether the molecular subtypes showed a preference to relapse to specific distant organs
  • We verified this by checking that the site of relapse did not show an association with prognosis, which means for this study, that pairing of a site of relapse to a subtype is not based on common prognostic outcome
  • Outside the scope of this article, it may be that other biological relevant breast cancer signatures, such as the wound-response, stromal, and hypoxia signatures, are characteristic of a phenotype that may facilitate a metastasis in a specific organ
  • A recent example is the implication of hypoxia and HIF-1 in osteolytic bone metastases in an animal model
  • The observations reported here indicate that the five major molecular subtypes in breast cancer are distinct with regard to primary tumor characteristics, tumor aggressiveness, and response to certain types of chemotherapy, they are clearly different with regard to their ability to metastasize to distant organ(s)

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