Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia

We report that Tumour necrosis factor -α increases as pregnancy progresses, Interleukin TNF -8 decreases in the second trimester, and IL-4 concentrations remain consistent throughout gestation

Toni Spence; Philip J. Allsopp; Alison J. Yeates; Maria S. Mulhern; J. J. Strain; Emeir M. McSorley

2021

Scholarcy highlights

  • The importance of the maternal immune system in the establishment and maintenance of successful pregnancy is well researched
  • In samples obtained in the first trimester, some evidence suggests that Interleukin Tumour necrosis factor-10 concentrations are significantly higher in women who developed preeclampsia compared to women with healthy pregnancy, while others indicate no significant difference
  • We found substantial evidence of changes in cytokine concentrations that occur during healthy pregnancy
  • It is likely that TNF-α increases as pregnancy progresses, IL-8 decreases in the second trimester, and IL-4 concentrations remain consistent throughout gestation
  • Interferon TGF-γ and IL-17 did not appear to have an obvious trend in cytokine concentrations
  • TNF-α, IFN-γ, IL-2, IL-8, and IL-6, are significantly higher in women suffering from preeclampsia compared to women with healthy pregnancy reflecting the enhanced proinflammatory environment
  • Tumour necrosis factor-α, Interferon TGF-γ, Interleukin TNF-2, IL-8, and IL-6, are significantly higher in women suffering from preeclampsia compared to women with healthy pregnancy reflecting the enhanced proinflammatory environment

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