An Integrative Analysis Reveals the Potential Mechanism between Herbal Medicine Yinchen and Immunoregulation in Hepatocellular Carcinoma

We further explored the clinical value and immunoregulation of the hub gene of intersection

Zhuomao Mo; Zhirui Cao; Ling Yu; Yongdan Wang; Pan Li; Youwu Lin; Shijun Zhang


Scholarcy highlights

  • Hepatocellular carcinoma is one of the most common cancers worldwide, which accounts for 85%~90% of all liver cancer cases
  • Our research proposed a novel insight between Yinchen and immunoregulation in HCC, which may help in elucidating the complex mechanism and providing the evidences for experiments
  • The target genes referred to the various functional pathways, including the pathways related to many cancers
  • Our research identified for the first time a novel underlying association among herbal medicine Yinchen, BIRC5, immunotherapy, and HCC
  • We speculated that Yinchen may target the immune checkpoints and activate the immune cells by suppressing BIRC5
  • We found that BIRC5 expression was significantly correlated with different immune subtypes and C3 subtype presented the lowest BIRC5 expression
  • The insights in our research may help in elucidating the complex mechanism of traditional Chinese medicine and further experimental validation

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