A Review on Oxidative Stress, Diabetic Complications, and the Roles of Honey Polyphenols

This review focuses on the various prospects of using honey as an antidiabetic agent and the potential insights

Visweswara Rao Pasupuleti; Chandra Sekhar Arigela; Siew Hua Gan; Sirajudeen Kuttulebbai Nainamohamed Salam; Kumara Thevan Krishnan; Nurhanan Abdul Rahman; Mohammad Saffree Jeffree

2020

Scholarcy highlights

  • Diabetes mellitus is characterized mainly by hyperglycaemia occurring due to defects in insulin secretion, insulin action, or both
  • The roles of insulin resistance, oxidative stress, honey as an antidiabetic, and the nuclear factor erythroid 2-related factor 2/antioxidant response elements pathway involved in type 2 diabetes mellitus, as well as the current state of efforts aimed at exploiting natural products to increase the number of armamentariums against diabetes are reviewed
  • The burden in the community is increasing with chronic illnesses including diabetes mellitus, hypertension, atherosclerosis, and cancer
  • The evidence that oxidative stress plays a substantial role in pathogenesis or disorders suggests that antioxidants can be beneficial
  • Various types of honey have been investigated for their antimicrobial, antidiabetic, anti-hyper-cholesterol, anti-inflammatory, antioxidant, and wound-healing effects
  • In an experiment on normal rats which received honey supplementation, the glycated haemoglobin was considerably reduced, where α-glucosidase and α-amylase were inhibited, the crucial enzymes involved in ameliorating blood glucose level elevation as a result of carbohydrate breakdown
  • It is highly imperative that several clinical and experimental trials are carefully designed and planned since they are often required to verify the efficacy of honey either alone or as an adjuvant treatment

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