Update in the Early Management and Reperfusion Strategies of Patients with Acute Ischemic Stroke

This review aims to provide a focused up-to-date review for the early management of adult patients with Acute ischemic stroke and introduce the new upcoming areas of ongoing research

Aldo A. Mendez; Edgar A. Samaniego; Sunil A. Sheth; Sudeepta Dandapat; David M. Hasan; Kaustubh S. Limaye; Bradley J. Hindman; Colin P. Derdeyn; Santiago Ortega-Gutierrez


Scholarcy highlights

  • Stroke ranks number five among all causes of death in the United States and is a leading cause of serious longterm disability
  • The run-in phase of this study has provided essential information to help in the nal design of their study. ey have shown that their average door-to-needle time on the Mobile Stroke Units is comparable with the fastest ED door-to-needle times reported in the literature
  • A recent retrospectively analysis of patients who underwent endovascular thrombectomy reported that greater values of systolic blood pressure in the first 24 postprocedural are independently associated with greater severity of hemorrhages within 48 hours and worse functional outcomes
  • Substantive advances have been made in the acute management of acute ischemic stroke
  • Recent trials demonstrating the benefit of endovascular therapy have brought a new era in the treatment of stroke
  • In the intention-to-treat analysis, there was no significant difference in disability-free survival at day 90 with MT
  • That endovascular thrombectomy has been established as part of the standard of care, further research is needed to continue to optimize existing strategies at prehospital and posthospital care and develop newer methods that incorporate adjunctive emerging reperfusion therapies

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