Activation of the Nrf2-Keap 1 Pathway in Short-Term Iodide Excess in Thyroid in Rats

We aim to investigate the effect of normal iodide intake, 10 times high iodide intake, and 100 times high iodide intake on Days 7, 14, and 28 on the antioxidative action of Srx and Peroxiredoxin 3 via Nrf2Keap 1 pathway in the thyroid of rats

Tingting Wang; Xue Liang; Iruni Roshanie Abeysekera; Umar Iqbal; Qi Duan; Gargi Naha; Laixiang Lin; Xiaomei Yao

2017

Scholarcy highlights

  • Iodine being a critical constituent of thyroid hormones is essential for normal growth and development in all vertebrates
  • We aim to investigate the effect of normal iodide intake, 10 times high iodide intake, and 100 times high iodide intake on Days 7, 14, and 28 on the antioxidative action of Srx and Peroxiredoxin 3 via Nrf2Keap 1 pathway in the thyroid of rats
  • In all the different time periods, there was a significant increase in the urinary iodine concentration among 10 HI and 100 HI when compared to the NI group
  • Between any of the iodide intake groups, there was no significant difference in the urinary iodine concentration on Day 14 and Day 28 when compared to Day 7
  • We demonstrated that the expression of Nuclear factor erythroid 2-related factor 2 was significantly increased, while Keap 1 was significantly decreased in the 100 HI group when compared to the NI or 10 HI group on Days 7, 14, and 28
  • Our results highlight that the activation of Nrf2-Keap 1, Srx, and Prx 3 antioxidative defense mechanisms may play a crucial role in protecting the thyroid from iodide excess induced oxidative stress on Days 7, 14, and 28
  • normal iodide intake: Normal iodide intake HI: High iodide intake reactive oxygen species: Reactive oxygen species H2O2: Hydrogen peroxide Nrf2: Nuclear factor erythroid 2-related factor 2 Keap 1: Kelch-like ECH-associated protein 1 antioxidant response element: Antioxidant response element Prx: Peroxiredoxin Srx: Sulfiredoxin Prx 3: Peroxiredoxin 3 TT4: Total thyroxine TT3: Total triiodothyronine FT4: Free thyroxine FT3: Free triiodothyronine TSH: Thyrotropin Least Significant Difference: Least significant difference

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