The Advances of Carbon Nanotubes in Cancer Diagnostics and Therapeutics

We summarized the properties of Carbon nanotubes and the method of CNTs functionalization and illustrated their application in cancer diagnosis and therapy

Zhou Chen; Aili Zhang; Xiaobing Wang; Jing Zhu; Yamin Fan; Hongmei Yu; Zhaogang Yang

2017

Scholarcy highlights

  • Nanotechnology as one branch of engineering, which deals with the manipulation of individual molecules and atoms, has got much attention in recent years
  • single-walled CNTs-WT1 can be rapidly uptaken by APC in vitro, which is dependent of dose. They used SWCNTs-WT1 adjuvant to immune mice and found that mice can cause a specific humoral immune reaction, and they do not see other response against the peptide alone against the peptide mixed with the adjuvant. These results suggested that SWCNTs can be a new tool to deliver poorly immunogenic peptides to the immune system, enhancing the efficiency of vaccine treatment
  • Carbon nanotubes have been functionalized via covalent and noncovalent interaction
  • Functionalized CNTs can be used as carriers to play their roles in delivery system
  • CNTs have more surface areas and internal antrums, which can be loaded with targeted ligands and filled with diagnostic or therapeutic agents
  • The emergence of new techniques for surface functionalization may help reduce these disadvantages. We believe that this novel CNT based platform can provide us with a safer and more effective way for the cancer therapy in the near future
  • We believe that this novel Carbon nanotubes based platform can provide us with a safer and more effective way for the cancer therapy in the near future

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