Role of ROS and RNS Sources in Physiological and Pathological Conditions

These results suggest a damaging role of P450 induction in hepatic tissue, a consequence of the high rates of production of reactive oxygen species by P450 is its own labilization and subsequent rapid inactivation

Sergio Di Meo; Tanea T. Reed; Paola Venditti; Victor Manuel Victor

2016

Scholarcy highlights

  • The existence of free radicals, known in chemistry since the beginning of the 20th century, was discovered in biological systems in 1954
  • The superoxide dismutase discovery inspired a large number of studies, which contributed to the knowledge of the reactive oxygen species, even though for several decades they were thought to cause exclusively damaging effects
  • It was reported that vitamin E supplementation prevents the increase in activator and coactivator levels and mitochondrial population adaptation to physical training. These results suggest that the ROS produced during each session of exercise training are able to regulate cellular functions acting as signals regulating molecular events crucial for adaptive responses of liver, muscle, and heart
  • Available data indicate that mitochondria are a significant source of ROS, but evidence for or against mitochondria being the main source of cellular ROS is lacking
  • Less information is available on role played by other cellular ROS sources in these processes
  • Accumulating evidence favors the idea that, in many cells and conditions, such sources play a role in cellular oxidative damage as well as in survival mechanisms activated by oxidative stress, contributing to tissue rescue from excessive damage and dysfunction

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