Chemistry and Biological Activities of Flavonoids: An Overview

Flavonoids consist of a large group of polyphenolic compounds having a benzo-γ-pyrone structure and are ubiquitously present in plants

Shashank Kumar

2013

Scholarcy highlights

  • Flavonoids consist of a large group of polyphenolic compounds having a benzo-γ-pyrone structure and are ubiquitously present in plants
  • The chemical nature of flavonoids depends on their structural class, degree of hydroxylation, other substitutions and conjugations, and degree of polymerization. Recent interest in these substances has been stimulated by the potential health benefits arising from the antioxidant activities of these polyphenolic compounds
  • Functional hydroxyl groups in flavonoids mediate their antioxidant effects by scavenging free radicals and/or by chelating metal ions
  • It has been shown that the flavanol epigallocatechin-3-gallate inhibited fatty acid synthase activity and lipogenesis in prostate cancer cells, an effect that is strongly associated with growth arrest and cell death
  • The ability of flavonoids to inhibit the activity of the efflux facilitator PIN and MDR proteins depends on the presence of the catechol group in the B ring of the flavonoid skeleton
  • Variety of flavonoids found in the nature possesses their own physical, chemical, and physiological properties
  • Further achievements will provide newer insights and will certainly lead to a new era of flavonoid based pharmaceutical agents for the treatment of many infectious and degenerative diseases

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