Stress Evaluation in Adult Patients with Atopic Dermatitis Using Salivary Cortisol

The results showed that the saliva cortisol level was significantly higher in atopic dermatitis patients compared to healthy subjects and lactate dehydrogenase levels were positively correlated with the SCORAD index

Megumi Mizawa; Masaki Yamaguchi; Chieko Ueda; Teruhiko Makino; Tadamichi Shimizu

2013

Scholarcy highlights

  • Atopic dermatitis is a common chronic inflammatory skin disease characterized by inflammatory infiltration, extensive pruritus, and a clinical course defined by symptomatic flares and remissions
  • Significant correlation between the SCORAD index and salivary cortisol levels. No significant correlations were observed between the salivary cortisol level and the serum levels of thymus and activation-regulated chemokine, IgE, and lactate dehydrogenase or the number of peripheral blood eosinophils
  • It was observed that the salivary cortisol level was significantly increased in atopic dermatitis patients in comparison to healthy subjects
  • This suggests that AD patients might be suffering from chronic stress
  • Cortisol is secreted from the adrenal cortex in the HPA axis, and its level increases due to acute stress, and due to chronic stress, such as that resulting from stigmatization, social isolation, and discrimination 8
  • The present study showed that the levels of salivary cortisol were significantly correlated with the SCORAD
  • These results suggest that the saliva cortisol level is a useful biomarker to evaluate the stress in atopic dermatitis patients and to help physicians in order to plan more effective treatment strategies for these patients

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