Angiogenic growth factor mRNA responses in muscle to a single bout of exercise

We suggest that vascular endothelial growth factor, basic fibroblast growth factor, and TGF-beta 1 may be involved in the angiogenic response to exercise and that reduced intracellular PO2 may be part of the stimulus to such growth factor production

E. C. Breen

2017

Scholarcy highlights

  • A major adaptation to exercise is new capillary formation in skeletal muscle
  • In 9-wk-old female Wistar rats, mRNA expression for these three growth factors in gastrocnemius muscle was examined by quantitative Northern analysis after a single 1-h run at 15 or 20 m/min at 10 degrees incline in room air
  • A third group ran at 15 m/min in 12% O2, and resting control groups were included at inspired O2 fractions of 0.21 and 0.12
  • Exercise significantly increased mRNA levels two- to fourfold, which was evident over the first 4 h postexercise; by 8 and 24 h, mRNA levels returned to baseline
  • MRNA levels were significantly higher after exercise at 20 than at 15 m/min
  • We suggest that vascular endothelial growth factor, basic fibroblast growth factor, and TGF-beta 1 may be involved in the angiogenic response to exercise and that reduced intracellular PO2 may be part of the stimulus to such growth factor production

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