Analysis of intracellular oxygenation of isolated adult cardiac myocytes

The analysis shows that the intracellular diffusion coefficient for O2 must be below 4 X 10(-6) cm2/s for a substantial intracellular gradient to occur

D. P. Jones; F. G. Kennedy

2017

Scholarcy highlights

  • The influence of cellular shape, cellular O2 consumption rate, and intracellular diffusion coefficient for O2 on the magnitude of intracellular O2 gradients during hypoxia was analyzed with the model of Boag
  • The analysis shows that the intracellular diffusion coefficient for O2 must be below 4 X 10(-6) cm2/s for a substantial intracellular gradient to occur
  • The analysis does not account for the correspondence of intracellular P50 values of Mb oxygenation and cytochrome a + a3 oxidation
  • This implies that there exists an intracellular heterogeneity of either Mb distribution, mitochondrial distribution, or mitochondrial respiratory characteristics. Such heterogeneity would further contribute to diffusion limitation of O2 supply during hypoxia and could be a major factor underlying the cardiac myocyte structure-function relationship

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