Breast Cancer: Radiogenomic Biomarker Reveals Associations among Dynamic Contrast-enhanced MR Imaging, Long Noncoding RNA, and Metastasis

Because the long noncoding RNA Homeobox transcript antisense intergenic RNA is a known regulator of metastatic progression in breast cancer, we evaluated whether the enhancing rim fraction score was associated with HOTAIR expression

Shota Yamamoto

2015

Scholarcy highlights

  • To perform a radiogenomic analysis of women with breast cancer to study the multiscale relationships among quantitative computer vision–extracted dynamic contrast material–enhanced magnetic resonance imaging phenotypes, early metastasis, and long noncoding RNA expression determined by means of high-resolution next-generation RNA sequencing
  • Radiogenomic analysis allowed identification of three previously uncharacterized and five named long noncoding RNA significantly associated with high enhancing rim fraction, including Homeobox transcript antisense intergenic RNA, a known predictor of poor metastasis-free survival in patients with breast cancer
  • Despite an increasing appreciation of the critical role lncRNAs play in cell fate, little is known about their relationship with systems-level phenotypes captured at noninvasive imaging
  • We performed a radiogenomic analysis of women with breast cancer to study the multiscale relationships among quantitative computer vision–extracted DCE MR imaging phenotypes, early metastasis, and lncRNA expression determined by means of high-resolution next-generation RNA sequencing
  • These findings begin to reveal an initial portrait of the multiscale relationships between quantitative DCE MR imaging phenotypes, early metastasis, and lncRNA expression observed at high resolution RNA sequencing, which suggests that the approach is both feasible and scalable
  • Cox regression analysis performed on the training set by using the 21 imaging features compared with MFS allowed identification of the enhancing rim fraction score as the only significant imaging feature associated with early occurrence of metastasis
  • We identified the ERF phenotype to be significantly associated with the lncRNA HOTAIR, which has been implicated in breast cancer metastasis
  • Developments in next-generation sequencing technologies are allowing RNA sequencing at increasing

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