Novel Effects of Nitric Oxide

We have reviewed the non–3′,5′-cyclic-guanosine-monophosphate–mediated effects of Nitric oxide including modifications of proteins, lipids, and nucleic acids

Karen L Davis; Emil Martin; Illarion V Turko; Ferid Murad


Scholarcy highlights

  • Nitric oxide, a simple free radical gas, elicits a surprisingly wide range of physiological and pathophysiological effects
  • NO interacts with soluble guanylate cyclase to evoke many of these effects
  • NO can interact with molecular oxygen and superoxide radicals to produce reactive nitrogen species that can modify a number of macromolecules including proteins, lipids, and nucleic acids
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