Innate Immune Recognition

The innate immune system is a universal and ancient form of host defense against infection

Charles A. Janeway

2002

Scholarcy highlights

  • The innate immune system is a universal and ancient form of host defense against infection
  • These receptors evolved to recognize conserved products of microbial metabolism produced by microbial pathogens, but not by the host
  • Toll-like receptors play a major role in pathogen recognition and initiation of inflammatory and immune responses
  • Stimulation of Toll-like receptors by microbial products leads to the activation of signaling pathways that result in the induction of antimicrobial genes and inflammatory cytokines
  • Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens
  • We begin by introducing interferon and the JAK-STAT signaling pathway to ...Read More

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