Characteristics of Changes in Lipid Peroxidation and Na+/K+-ATPase Activity in the Cortex of Old Rats in Conditions of Two-Vessel Cerebral Ischemia/Reperfusion

We found a late accumulation of lipid peroxidation products, triene conjugates and Schiff bases, and a decrease in Na+/K+-ATPase activity in the cerebral cortex of old rats as compared with young animals

I. I. Zorina; E. A. Fokina; I. O. Zakharova; L. V. Bayunova; A. O. Shpakov

2020

Scholarcy highlights

  • The success of studies on the neuroprotective properties of compounds depends on the used model of diseases of the central nervous system on animals
  • The approaches widely used to model cerebral ischemia/reperfusion were developed on young animals and may not be as efficient or may not be suitable at all for modeling on old animals, which are recommended for preclinical trials
  • We found a late accumulation of lipid peroxidation products, triene conjugates and Schiff bases, and a decrease in Na+/K+-ATPase activity in the cerebral cortex of old rats as compared with young animals
  • It is necessary to take into account the identified differences in these mechanisms in the development and testing of compounds that will be subsequently used for the treatment of elderly patients with stroke and ischemic brain damage

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