Hydrogen peroxide produced inside mitochondria takes part in cell-to-cell transmission of apoptotic signal

In monolayer of HeLa cells treated with tumor necrosis factor, apoptotic cells formed clusters indicating possible transmission of apoptotic signal via the culture media

O. Yu. Pletjushkina

2006

Scholarcy highlights

  • In monolayer of HeLa cells treated with tumor necrosis factor, apoptotic cells formed clusters indicating possible transmission of apoptotic signal via the culture media
  • TNF, staurosporine, or H2O2 treatment of the inducer cells is shown to initiate apoptosis on the recipient coverslip. This effect is increased by a catalase inhibitor aminotriazole and is arrested by addition of catalase or by pre-treatment of either the inducer or the recipient cells with nanomolar concentrations of mitochondria-targeted cationic antioxidant MitoQ, which arrests H2O2-induced apoptosis
  • It is concluded that reactive oxygen species produced by mitochondria in the apoptotic cells initiate the release of H2O2 from these cells
  • The H2O2 released is employed as a long-distance cell suicide messenger
  • Pletjushkina, O.Y., Fetisova, E.K., Lyamzaev, K.G. et al Hydrogen peroxide produced inside mitochondria takes part in cell-to-cell transmission of apoptotic signal

Need more features? Save interactive summary cards to your Scholarcy Library.