Mutator and MULE Transposons

A distinguishing feature of transposable elements is their propensity to induce mutations

Damon Lisch

2015

Scholarcy highlights

  • A distinguishing feature of transposable elements is their propensity to induce mutations
  • This is based on the observation that inactivated lines do not silence otherwise active lines, suggesting the absence of a heritable factor that is competent in inactivate Mutator elements
  • The Mutator system has proved to be a remarkable source of information concerning the biology and evolution of transposable elements
  • Analysis of the function of MURB will be of particular interest, given its somewhat mysterious origin and function
  • As we know that a 35S-driven mudrA cDNA is sufficient to cause somatic excisions but not insertions of a reporter element, it will be interesting to examine a line that contains transgenic copies of both mudrA and mudrB to see if insertional activity can be restored in trans and whether or not both can function in a heterologous system
  • Mutagenic potential is regularly lost in about 10% of the progeny of a standard Mutator line upon out crossing or self-fertilization
  • It will be interesting to determine whether MURB interacts with proteins other than MURA, and whether constitutive expression of MURB has more general effects than those we see on Mutator element activity

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