The Gut Mucosal Viral Reservoir in HIV-Infected Patients Is Not the Major Source of Rebound Plasma Viremia following Interruption of Highly Active Antiretroviral Therapy

We evaluated longitudinal changes in viral replication and emergence of viral variants in the context of T cell homeostasis and gene expression in gut-associated lymphoid tissue of three HIV-positive patients who initiated highly active antiretroviral therapy during primary HIV infection but opted to interrupt therapy thereafter

Paula Lerner; Moraima Guadalupe; Richard Donovan; Jason Hung; Jason Flamm; Thomas Prindiville; Sumathi Sankaran-Walters; Michael Syvanen; Joseph K. Wong; Michael D. George; Satya Dandekar

2011

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