Pediatric viral gastroenteritis during eight years of study

This paper summarizes data from what may be the longest continuous study in the United States for recently described enteritis viruses

C D Brandt; H W Kim; W J Rodriguez; J O Arrobio; B C Jeffries; E P Stallings; C Lewis; A J Miles; R M Chanock; A Z Kapikian; R H Parrott

2020

Scholarcy highlights

  • Research Foundation of Children's Hospital National Medical Center' and Department of Child Health and Development, George Washington University School of Medicine and Health Sciences,2 Washington, D.C. 20010; and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 202053
  • During the period January 1974 through July 1982, fecal samples from 1,537 pediatric inpatients with gastroenteritis were tested for enteric viruses by electron microscopic and rotavirus enzyme-linked immunosorbent assay techniques
  • Rotaviruses were detected in 34.5% of these patients, enteric adenoviruses were detected in 4.7%, -27-nm viruses were detected in 1.6%, and at least one of these agents was found in 40.1% of the study subjects
  • In the period January 1974 through July 1982, one or more fecal samples from 1,537 pediatric patients who were hospitalized with acute gastroenteritis at this medical center were tested for enteric viruses by electron microscopy and rotavirus enzyme-linked immunosorbent assay techniques
  • When data from the first 96 months of study were combined, the proportion of gastroenteritis inpatients in whom an enteric virus was demonstrated by EM, immune EM, or rotavirus ELISA rose steadily from 7.4% in September to a peak of 72.0% in January and steadily declined to 2.9% in August
  • Rotaviruses, adenoviruses, and -27-nm viruses apparently are causally associated with gastroenteritis in this locale, since each of these groups of viruses has been detected by EM or IEM significantly more often in fecal specimens from patients with enteritis than from control subjects
  • A considerable effect of factors related to cold weather and low indoor humidity is suggested by the clocklike precision of the annual wave of rotavirus infection in Washington, D.C., which has been more regular and predictable than that of any pediatric pathogen which this laboratory has investigated, including respiratory syncytial virus , influenza A and B viruses , the respiratory adenoviruses , parainfluenza viruses

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