Chemical characterization of the ester-linked 3-hydroxy fatty acyl-containing lipids in Mycobacterium tuberculosis.

Bacteriol. 176:2962–2969, 1994), we reported the occurrence of 21 3-hydroxy fatty acids in the methanolysis products of different mycobacterial species

S Alugupalli


Scholarcy highlights

  • Tuberculosis remains the leading cause of death in the world from a single pathogen
  • We recently characterized 21 3-hydroxy fatty acids, i.e., straight-chain and 2-Me and 2,4,6-tri-Me branched-chain fatty acids, in 27 strains belonging to 12 mycobacterial species
  • According to their 3-OH-FA patterns, the mycobacterial species could be subdivided into six groups, suggesting a taxonomic interest for these fatty acids
  • Virulent strains of Mycobacterium tuberculosis exhibited an unique pattern of 3-OH-FAs in that they contain multi-Me branched long chain hydroxy fatty acids, the potential precursors of fatty acids found in the biologically important mycobacterial lipids
  • The present study was undertaken in order to chemically characterize the ester-linked native forms of straight- and Me branched-chain 3-OH-FAs in M. tuberculosis
  • The isolation of 3-oxo-2-tetradecyloctadecanoate-containing phospholipid in a cell extract of Corynebacterium diphtheriae, thought to be the acyl carrier-containing product of a Claisen-type condensation leading to corynomycolic acid, suggests that the 3-OH-FA-containing phosphatidyl ethanolamine may play a role in the biosynthesis of complex fatty acids in actinomycetes, including mycobacteria

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