Liposomes containing anti-idiotypic antibodies: an oral vaccine to induce protective secretory immune responses specific for pathogens of mucosal surfaces.

We provide evidence for the first time that introduction of an anti-id vaccine into the mucosal immune system can provide protective immunity

S Jackson

2020

By using a gnotobiotic rat model system to study the induction of protective immune responses by anti-idiotype vaccines specific for antibodies directed at the cariogenic microorganism Streptococcus mutans, it was shown that administration of such an anti-id vaccine provided partial protection against dental caries after challenge with virulent microorganisms
The animals were bled, and the serum samples were assayed by enzyme-linked immunosorbent assay for anti-S. mutans activity
When the protective effect of anti-id immunization into salivary gland areas was examined, the results indicated that protective effects were demonstrable
A number of investigations have centered on the establishment of protective immune responses by administration of anti-id vaccines
Antibody levels were higher at each dilution in the anti-id-immunized group, there were no significant differences between groups
Attempts to induce protection against pathogens of mucosal surfaces by using anti-id vaccines targeted at the secretory immune system have not been reported
The amount of protection observed in this study was less than that observed when animals were given an oral vaccine consisting of liposomes containing purified antigens of mutans streptococci , we assume that subsequent experiments using an increased antigen dose and possibly an oral adjuvant such as cholera toxin will demonstrate more efficient protection

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