Liposomes containing anti-idiotypic antibodies: an oral vaccine to induce protective secretory immune responses specific for pathogens of mucosal surfaces.

We provide evidence for the first time that introduction of an anti-id vaccine into the mucosal immune system can provide protective immunity

S Jackson


Scholarcy highlights

  • By using a gnotobiotic rat model system to study the induction of protective immune responses by anti-idiotype vaccines specific for antibodies directed at the cariogenic microorganism Streptococcus mutans, it was shown that administration of such an anti-id vaccine provided partial protection against dental caries after challenge with virulent microorganisms
  • The animals were bled, and the serum samples were assayed by enzyme-linked immunosorbent assay for anti-S. mutans activity
  • When the protective effect of anti-id immunization into salivary gland areas was examined, the results indicated that protective effects were demonstrable
  • A number of investigations have centered on the establishment of protective immune responses by administration of anti-id vaccines
  • Antibody levels were higher at each dilution in the anti-id-immunized group, there were no significant differences between groups
  • Attempts to induce protection against pathogens of mucosal surfaces by using anti-id vaccines targeted at the secretory immune system have not been reported
  • The amount of protection observed in this study was less than that observed when animals were given an oral vaccine consisting of liposomes containing purified antigens of mutans streptococci , we assume that subsequent experiments using an increased antigen dose and possibly an oral adjuvant such as cholera toxin will demonstrate more efficient protection

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