Antimicrobial Growth Promoters Used in Animal Feed: Effects of Less Well Known Antibiotics on Gram-Positive Bacteria

The aim of this review is to summarize the data available on the lesser known antibiotics, giving special attention to their spectrum of antibacterial activity and their effects on the intestinal flora, resistance mechanisms, and prevalence of resistance

Patrick Butaye; Luc A. Devriese; Freddy Haesebrouck

2003

Scholarcy highlights

  • After the introduction of the therapeutic use of antibiotics, the growth-promoting effect of these products in chickens was discovered by feeding fermentation offal from the chlortetracycline production of Streptomyces aureofaciens
  • The aim of this review is to summarize the data available on the lesser known antibiotics, giving special attention to their spectrum of antibacterial activity and their effects on the intestinal flora, resistance mechanisms, and prevalence of resistance
  • Some of the antibiotics that are used today or that have been used in the past for growth promotion in animal husbandry have been well investigated
  • Much research is being done on products active on these organisms since major problems exist in the therapy of infections caused by multiresistant gram-positive bacteria in humans
  • New chemical adaptations to products used solely for growth promotion might be useful in therapy dealing with multiresistant grampositive bacterial infections
  • The fact that some antibiotics treated in this review are used solely in animals offers opportunities to study transfers of resistance-determining genes between different ecosystems
  • Fragmentary information is available on the possible spread of resistance genes from animals to humans

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