Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Apoptosis plays an important role during neuronal development, and defects in apoptosis may underlie various neurodegenerative disorders

Zhengui Xia; Martin Dickens; Joël Raingeaud; Roger J. Davis; Michael E. Greenberg

2006

Scholarcy highlights

  • Apoptosis plays an important role during neuronal development, and defects in apoptosis may underlie various neurodegenerative disorders
  • nerve growth factor withdrawal led to sustained activation of the JNK and p38 enzymes and inhibition of ERKs
  • The effects of dominant-interfering or constitutively activated forms of various components of the JNK-p38 and ERK signaling pathways demonstrated that activation of JNK and p38 and concurrent inhibition of ERK are critical for induction of apoptosis in these cells
  • The dynamic balance between growth factor-activated ERK and stress-activated JNK-p38 pathways may be important in determining whether a cell survives or undergoes apoptosis

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