Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

The role of the cell-surface molecule CTLA-4 in the regulation of T cell activation has been controversial

Paul Waterhouse; Josef M. Penninger; Emma Timms; Andrew Wakeham; Arda Shahinian; Kelvin P. Lee; Craig B. Thompson; Henrik Griesser; Tak W. Mak

2006

Key concepts

Scholarcy highlights

  • The role of the cell-surface molecule CTLA-4 in the regulation of T cell activation has been controversial
  • CTLA-4-deficient T cells proliferated spontaneously and strongly when stimulated through the T cell receptor, they were sensitive to cell death induced by cross-linking of the Fas receptor and by gamma irradiation
  • CTLA-4 acts as a negative regulator of T cell activation and is vital for the control of lymphocyte homeostasis

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