Mediation of c-Myc-Induced Apoptosis by p53

These results suggest that p53 mediates apoptosis as a safeguard mechanism to prevent cell proliferation induced by oncogene activation

Heiko Hermeking; Dirk Eick

2006

Scholarcy highlights

  • The cellular proto-oncogene c-myc is involved in cell proliferation and transformation but is implicated in the induction of programmed cell death
  • The same characteristics have been described for the tumor suppressor gene p53, the most commonly mutated gene in human cancer
  • In quiescent p53-null fibroblasts, activation of c-Myc induced cell cycle reentry but not apoptosis. These results suggest that p53 mediates apoptosis as a safeguard mechanism to prevent cell proliferation induced by oncogene activation

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